Does Sugar Feed Tumors?

If you’re a cancer survivor chances are that you’ve had a health professional, friend or acquaintance tell you to avoid sugar because “sugar feeds cancer cells.”

Google “sugar and cancer” and over 88 million hits come up. No wonder there’s a lot of confusion about this topic – for health professionals and everyone else.

This was the topic of a teleconference I attended today for Registered Dietitians working in oncology. I’ll bottom line the information and share some interesting facts.

1.            Sugar feeds every cell in the body. So yes, sugar does feed cancer cells, but we could not live without sugar or glucose in our blood.

2.            Insulin Resistance may be the real concern. When you aren’t able to move sugar from the blood into the cell with normal levels of insulin, that is considered insulin resistance and your body has to make more insulin. Insulin resistance is associated with increased risk of certain cancers.

3.            It is important to focus on the big picture of your diet and eating habits. Your food choices should be empowering, not a source of stress after a cancer diagnosis.

Here’s what the presenter suggested you can do to limit high insulin levels:

  • Maintain a healthy weight
  • Exercise and be physically active
  • Eat it whole – choose less processed foods
  • Avoid “naked carbs.” That is – don’t eat high carbohydrate foods by themselves. Be sure to include foods with some protein and/or healthy fat along with high carbohydrate foods. (nuts and fruit; Bean and vegetable salad with dressing)
  • Eat small, frequent meals. This can keep blood sugar stable and keep hunger and fatigue in check. But emphasize the smaller size of meals and snacks if you are eating more often.

The New American Plate is a great model for keeping meals and snacks balanced. One of the final slides of the presentation noted that our goal is not to eliminate any food groups (such as grains or other starchy foods) but to make better choices in all of them.

If you are a health professional and want to learn more about insulin resistance, diabetes and cancer risk, visit our Health Professionals and Educators eCommunity and read AICR’s InDepth The Diabetes-Cancer Link.


AICR’s Cancer Research Update: The Special Edition

AA045219Every issue of AICR’s biweekly e-publication, Cancer Research Update, delivers exactly what its title promises: Quick summaries of the latest research on diet, physical activity, weight and cancer, delivered straight to your inbox.

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The latest issue of CRU is a special edition: We present highlights from last week’s AICR Research Conference on Food, Nutrition, Physical Activity and Cancer – including the study that won top honors at our poster session.


Killing Cancer Cells with a Trojan Horse Strategy

Really fascinating talk by Johns Hopkins University researcher Peter L. Pedersen, PhD. Dr. Pedersen’s lab is studyiTrojanHorseng a compound that disrupts cancer cells’ mitochondria, the energy-producing part of the cell. If cancer cells can’t produce energy – they die. But disrupting the mitochondria in cancer cells is challenging: there are two sources of energy in cancer cells – only one in healthy cells – and the trick is to target only the cancer cells, not the healthy one, said Dr. Pedersen.

Dr. Pedersen presented his lab’s findings on a compound called 3-BrPA for short, which appears to stop liver cancer cells from producing energy. 3-BrPA sneaks into a cancer cells’ mitochondria using the Trojan Horse strategy. It’s structurally similar to another compound (lactic acid) found in high amounts in cancer cells. The cancer cells mistakes 3-BrPA for lactic acid and transports it inside. There, 3-BrPA gets in the way of the two pathways in energy production.

In animal studies, Dr. Pedersen’s lab has had promising results. For example, out of 33 animals with advanced liver cancer: the tumors of the 19 animals treated with 3-BrPA all went away within 1 to 4 weeks; the tumors in the untreated animals continued to grow.

While exciting, right now this research is still only in the laboratory phase.